For me I find once you hit hell, tag a long with a friend who has done the quests ahead and let him pull you to Act 3-4. There is really no point doing the same quests over and over again, it just takes a long time and you want exp / gold / items ASAP so you can get to inferno. Also, Tier 2 can be a real bitch in hell mode, lots of chain mobs, lots of corpse runs. So as soon as you can survive doing it solo, do the Asmoden runs which is the last quest of Act 3. For me it was when i hit level 55ish, if you have good gear, you probably can do it earlier.
It allows you to hand in two quests (kill asmoden) and the mini messenger quest after that. Asmoden drops mostly blues but he did drop one rare in the 30 runs I did which brought me from L55 to L59 in about 2hours + the normal grind will probably take 10+ hours minimum. There is a treasure bandit half the time, the mass spiders which give way more exp then they should and 4-5 chests. The mobs also sometimes have great drops and if i get chain blue mobs with molten / vortex i just quit the game and remake. Another alternative is to run past the blue chain mobs (wiz can teleport / monk can immortal / dh can strafe) and go straight to asmoden to farm the 2 quests.
I feel its the best farming spot in the game atm. Share yours!
Even the smallest donations help keep sc2sea running! All donations go towards helping our site run including our monthly server hosting fees and sc2sea sponsored community tournaments we host. Find out more here.