I suspect the league won't go much longer than 5 weeks of round-robin + some playoffs, with much bigger squads you're going to have a bunch of players who only play one game.
You can swap inactives out if you include in your post a 'shadow team' of people who didn't quite make the cut, and they can act as replacements through the season if required.
Okay that sounds much better. I have some arranging to do!
___________________________________
I don't blame you for being you, but you can't blame me for hating it
Even the smallest donations help keep sc2sea running! All donations go towards helping our site run including our monthly server hosting fees and sc2sea sponsored community tournaments we host. Find out more here.